Run Python with Apache on Ubuntu

sudo apt-get install libapache2-mod-wsgi-py3 

sudo apt-get install python3 libexpat1 -y 

sudo apt-get install apache2 apache2-utils ssl-cert libapache2-mod-wsgi -y 

a2enmod cgid

sites-available 

Non-SSL
<VirtualHost *:80>
        ServerName xxxx
        ServerAlias xxxx
        <Directory /var/www/xxxx>
                Options +ExecCGI
                AddHandler cgi-script .cgi .py
                Allow from all
                DirectoryIndex index.py
        </Directory>
         ProxyRequests Off
         ProxyPreserveHost On
         ProxyVia Full
        <Proxy *>
         Require all granted
        </Proxy>
        <Location />
          ProxyPass http://xxxx:port/
          ProxyPassReverse http://xxx:port/
        </Location>
        DocumentRoot /var/www/xxxx
</VirtualHost>

SSL
<VirtualHost *:443>
        ServerName xxx
        ServerAlias xxx
        SSLEngine on
        SSLCertificateFile /etc/ssl/certs/xxxx
        SSLCertificateKeyFile /etc/ssl/private/xxxx
        SSLCertificateChainFile /etc/ssl/xxxx
        <Directory /var/www/xxxx>
                Options +ExecCGI
                AddHandler cgi-script .cgi .py
                #Order allow,deny
                Allow from all
                AllowOverride All
                #Options +ExecCGI
                DirectoryIndex index.py
                Require all granted
        </Directory>
         ProxyRequests Off
         ProxyPreserveHost On
         ProxyVia Full
        <Proxy *>
         Require all granted
        </Proxy>
        <Location />
          ProxyPass http://xxxx:port/
          ProxyPassReverse http://xxx:port/
        </Location>
        DocumentRoot /var/www/xxxx
        ErrorLog ${APACHE_LOG_DIR}/error.log
        CustomLog ${APACHE_LOG_DIR}/access.log combined
</VirtualHost>

systemctl restart apache2

Home page of py added the first line:

#!/usr/bin/python

If python app is version 3 so need to map python to python3

Check Apache log
sudo tail -f /var/log/apache2/error.log

Check python version
python --version

Note: Python app must be up service