Run Python with Apache on Ubuntu

sudo apt-get install libapache2-mod-wsgi-py3 

sudo apt-get install python3 libexpat1 -y 

sudo apt-get install apache2 apache2-utils ssl-cert libapache2-mod-wsgi -y 

a2enmod cgid

sites-available 

Non-SSL
<VirtualHost *:80>
        ServerName xxxx
        ServerAlias xxxx
        <Directory /var/www/xxxx>
                Options +ExecCGI
                AddHandler cgi-script .cgi .py
                Allow from all
                DirectoryIndex index.py
        </Directory>
         ProxyRequests Off
         ProxyPreserveHost On
         ProxyVia Full
        <Proxy *>
         Require all granted
        </Proxy>
        <Location />
          ProxyPass http://xxxx:port/
          ProxyPassReverse http://xxx:port/
        </Location>
        DocumentRoot /var/www/xxxx
</VirtualHost>

SSL
<VirtualHost *:443>
        ServerName xxx
        ServerAlias xxx
        SSLEngine on
        SSLCertificateFile /etc/ssl/certs/xxxx
        SSLCertificateKeyFile /etc/ssl/private/xxxx
        SSLCertificateChainFile /etc/ssl/xxxx
        <Directory /var/www/xxxx>
                Options +ExecCGI
                AddHandler cgi-script .cgi .py
                #Order allow,deny
                Allow from all
                AllowOverride All
                #Options +ExecCGI
                DirectoryIndex index.py
                Require all granted
        </Directory>
         ProxyRequests Off
         ProxyPreserveHost On
         ProxyVia Full
        <Proxy *>
         Require all granted
        </Proxy>
        <Location />
          ProxyPass http://xxxx:port/
          ProxyPassReverse http://xxx:port/
        </Location>
        DocumentRoot /var/www/xxxx
        ErrorLog ${APACHE_LOG_DIR}/error.log
        CustomLog ${APACHE_LOG_DIR}/access.log combined
</VirtualHost>

systemctl restart apache2

Home page of py added the first line:

#!/usr/bin/python

If python app is version 3 so need to map python to python3

Check Apache log
sudo tail -f /var/log/apache2/error.log

Check python version
python --version

Note: Python app must be up service

After installed GCI Windows Server 2019 still error

This configuration section cannot be used at this path. This happens when the section is locked at a parent level. Locking is either by default (overrideModeDefault="Deny"), or set explicitly by a location tag with overrideMode="Deny" or the legacy allowOverride="false".

Solution:

%windir%\system32\inetsrv\appcmd.exe unlock config -section:system.webServer/handlers